Getting Started On
The Eversense® E3 CGM System

Welcome and congratulations on getting started with
the Eversense® E3 CGM System, the only long-term CGM
that lasts 6 months with a single sensor.

The Eversense® E3 Continuous Glucose Monitoring (CGM) System is indicated for continually measuring glucose levels for up to 180 days in persons with diabetes age 18 and older. The system is indicated for use to replace fingerstick blood glucose (BG) measurements for diabetes treatment decisions. Fingerstick BG measurements are still required for calibration primarily one time a day after day 21, and when symptoms do not match CGM information or when taking medications of the tetracycline class. The sensor insertion and removal procedures are performed by a health care provider. The Eversense E3 CGM System is a prescription device; patients should talk to their health care provider to learn more.

For important safety information, see https://www.ascensiadiabetes.com/eversense/safety-info/

Eversense, Eversense E3 Continuous Glucose Monitoring, and the Eversense logo are trademarks of Senseonics, Incorporated. Other brands and their products are trademarks or registered trademarks of their respective holders and are used solely for informative purposes. No relationship or endorsement should be inferred or implied.

DISCLAIMER

System set-up

In this tutorial , we briefly discuss the system 24-hour Warm Up Phase, and demonstrate how to enter your personalized glucose settings into the Eversense App.

But first, if you’ve not yet paired your Eversense E3 Smart Transmitter with the Eversense App, and linked the Smart Transmitter with your Eversense E3 sensor,
you should do that before continuing on.

24-HOUR WARM UP PHASE

Refer to the available System Set-Up Videos or your Eversense E3 CGM System Quick Reference Guide to assist you.

24-HOUR WARM UP PHASE

When you recently linked your E3 Smart Transmitter with the Eversense E3 sensor, the 24-hour Warm Up Phase countdown began, so we refer to this 24-hour time period as Day 1.

24-HOUR WARM UP PHASE

24-HOUR WARM UP PHASE

You won’t be getting any glucose data during Day 1, and it’s not necessary to wear your Smart Transmitter over your sensor.

But, it’s a great time to program your personalized glucose settings into your Eversense E3 CGM system.

To do this, your Eversense E3 Smart Transmitter and Eversense Mobile app must be communicating.

When you open your Eversense app, the Eversense E3 Smart Transmitter should connect automatically.

SET UP THE EVERSENSE MOBILE APP

Looking at the My Glucose Home screen, you’ll notice the transmitter battery icon on the top right is black.

The app status bar will say either Warm-Up Phase, or No Sensor Detected.

SET UP THE EVERSENSE MOBILE APP

If they are not connected, the icon will be grey and the app status bar will say No Transmitter Connected.

If No Transmitter Connected is displayed in the app status1 bar, jump to the Optional Connection Tips section of Day 1 in the menu.

SET UP THE EVERSENSE MOBILE APP

As you begin programming your personalized settings into your mobile app, you may see a No Sensor Detected alert pop-up. You can just tap “Not Now”.

Alerts and Notifications will be covered in the Day 2 and Day 3 chapters.

PERSONALIZED SETTINGS

To personalize your Eversense E3 CGM system, you’ll need your CGM settings for your glucose alerts levels and glucose target levels.

If you’re not sure of what personalized settings you should enter, consult with your health care provider and then come back to this training.

ENTER PERSONALIZED SETTINGS

To get to your personalized settings, tap on the menu icon to open the Main Menu.

ACCESS PERSONAL SETTINGS

Scroll down to tap Settings.

ACCESS PERSONAL SETTINGS

To get to your personalized settings, tap on the menu icon to open the Main Menu.

Then Tap Glucose.

ACCESS PERSONAL SETTINGS

Scroll down to tap Settings.

To get to your personalized settings, tap on the menu icon to open the Main Menu.

As you go into the glucose settings, you’ll see the Glucose Alerts section at the top.

Your glucose alerts will let you know when your glucose level has passed a critical high or low glucose threshold, as determined by your health care provider.

PERSONALIZE GLUCOSE ALERtS

Note that the default settings
are 250 mg/dL for a high glucose alert
and 65 mg/dL for a low glucose alert.

PERSONALIZE GLUCOSE ALERtS

As you go into the glucose settings, you’ll see the Glucose Alerts section at the top.

Your glucose alerts will let you know when your glucose level has passed a critical high or low glucose threshold, as determined by your health care provider.

When you want to personalize a glucose alert setting, simply tap on the setting you would like to change,

PERSONALIZE GLUCOSE ALERtS

Scroll to the desired value.
Then tap Done.

PERSONALIZE GLUCOSE ALERtS

When you want to personalize a glucose alert setting, simply tap on the setting you would like to change,

Always discuss the right alert settings for you with your healthcare provider.

Below Glucose Alerts is where
you set your glucose Target Range.

Your glucose target range is the area where you and your health care provider agree your glucose levels should be most of the time.

PERSONALIZE GLUCOSE TARGETS

PERSONALIZE GLUCOSE TARGETS

Again, simply tap on the setting
you would like to change, scroll to the desired value, and then tap Done.

Below Glucose Alerts is where
you set your glucose Target Range.

Your glucose target range is the area where you and your health care provider agree your glucose levels should be most of the time.

Note that your glucose target levels can only be programmed within the glucose alert levels you have set.

PERSONALIZE GLUCOSE TARGETS

Again, simply tap on the setting
you would like to change, scroll to the desired value, and then tap Done.

Below Glucose Alerts is where
you set your glucose Target Range.

Your glucose target range is the area where you and your health care provider agree your glucose levels should be most of the time.

You can also set Predictive and Rate of Change Alerts on this screen.

Predictive alerts can be especially helpful to CGM users.

However, if you are new to CGM, it might be best to wait to set either of these optional alerts until you discuss these settings with your healthcare provider.

See your User Guide for more information.

OPTIONAL PREDICTIVE & RATE ALERTS

Another important way that you can personalize your Eversense E3 CGM System is by customizing how your alerts sound, and how often alerts repeat.

PERSONALIZED SOUND SETTINGS

PERSONALIZED SOUND SETTINGS

From the My Glucose home screen, tap the Main Menu icon,

PERSONALIZED SOUND SETTINGS

From the My Glucose home screen, tap the Main Menu icon,

Then Settings on the Main Menu.

From the My Glucose home screen, tap the Main Menu icon,

Then Settings on the Main Menu.

Then choose Sound Settings.

PERSONALIZED SOUND SETTINGS

On the Sound Settings screen, you can tap on the alert name to open a ringtone menu that allows you to set a unique sound for that particular alert.

PERSONALIZED SOUND SETTINGS

On the Sound Settings screen, you can tap on the alert name to open a ringtone menu that allows you to set a unique sound for that particular alert.

For example, to change your low glucose alert sound, tap on the ringtone name to hear the sound and make your choice.

PERSONALIZED SOUND SETTINGS

On the Sound Settings screen, you can tap on the alert name to open a ringtone menu that allows you to set a unique sound for that particular alert.

For example, to change your low glucose alert sound, tap on the ringtone name to hear the sound and make your choice.

PERSONALIZED SOUND SETTINGS

You can change your choice by tapping on another ringtone name.

SNOOZE FEATURE

The Snooze feature allows you to set how often you would like your alert to repeat.

Simple tap on the snooze choice.

SNOOZE FEATURE

Scroll to set the time. Then tap Done.

The Snooze feature allows you to set how often you would like your alert to repeat.

Simple tap on the snooze choice.

SNOOZE FEATURE

In this example, where the low glucose alert snooze setting is set for 15 minutes, the user would receive a low glucose alert every 15 minutes as long as their glucose level remained below the user low glucose alert threshold.

Snooze is an important feature to understand if you feel that the frequency with which you receive alerts needs to be adjusted.

SNOOZE FEATURE

In this example, where the low glucose alert snooze setting is set for 15 minutes, the user would receive a low glucose alert every 15 minutes as long as their glucose level remained below their low glucose alert threshold.

If your Eversense E3 Smart Transmitter is not connecting automatically with the Eversense App, it is either because the smart transmitter is

  • Out of range of the mobile app,
  • Is out of charge,
  • Is not turned on, or
  • Needs to be re-paired to your mobile device.

Here are the steps to restore the connection.

OPTIONAL CONNECTION TIPS

Make sure your Eversense E3 Smart Transmitter is within 25 feet of the mobile app.

OPTIONAL CONNECTION TIPS

If your Eversense E3 Smart Transmiter hasn’t been charged in the last 24 hours, charge it now until the LED shows solid green. Note that when you remove the smart transmitter from the cradle after charging, it’s automatically turned on.

OPTIONAL CONNECTION TIPS

The steps for turning your Eversense E3 Smart Transmitter on, or off, are the same.

Press and hold the power button for about 5 seconds, until the smart transmitter vibrates. Then release the power button and watch the LED.

If it flashes green, it’s on.
If it flashes orange, it’s off.

OPTIONAL CONNECTION TIPS

If you need to re-pair your E3 Smart Transmitter with the Eversense mobile app, make sure your device Bluetooth is on, open your app, 

OPTIONAL CONNECTION TIPS

and put the smart transmitter in the discoverable mode by pressing the power button firmly three times until the LED alternates blinking green and orange.

You’ll see “Connecting” appear in the app status bar.

OPTIONAL CONNECTION TIPS

You have now completed the most important parts of personalizing your Eversense E3 CGM system.

If you’re still in the 24-hour warm-up phase and not wearing your Eversense E3 Smart Transmitter, it’s a good idea to turn it off.

To do this, press and hold the power button for about 5 seconds until the smart transmitter vibrates. This time, when you release the button, the LED will flash orange.

TURN OFF THE SMART TRANSMITTER

You’ve now completed Day 1 training. Once the 24-hour warm up phase is complete, you’re ready to move on to the Day 2 training presentation on System Initialization, and begin to receive glucose data.

DAY 1 TRAINING COMPLETE

Please contact your health care provider if you have a medical question or concerns about your diabetes treatment plan.

And contact Eversense Customer Care
if you have technical questions about
the Eversense E3 CGM System

Eversense Customer Care
1-844-SENSE4U (7367348)
Support@eversensediabetes.com

Once the 24-hour Warm Up Phase is complete, you’re ready to get your system started so that you can begin to receive glucose data.

SYSTEM INITIALIZATION

System INITIALIZATION

First - if possible, it’s always best to wait to start System Initialization early in the day.

This will allow you to complete all four required initialization calibrations before going to bed.

This presentation will walk you through the steps, and you can also refer to your Eversense E3 CGM System Quick Reference Guide.

SYSTEM INITIALIZATION

System INITIALIZATION

When you’re ready, start
by making sure that your
Eversense E3 Smart Transmitter
is fully charged.

SYSTEM INITIALIZATION

CHARGE SMART TRANSMITTER

Step 2 is to place your smart transmitter onto the adhesive patch.

Get an adhesive patch and peel off the paper backing with the Eversense logo.

SYSTEM INITIALIZATION

PLACE SMART TRANSMITTER ON ADHESIVE

The center of the patch is sticky, and this is where you should place your smart transmitter, as shown.

Press the smart transmitter firmly onto the adhesive.

SYSTEM INITIALIZATION

PLACE SMART TRANSMITTER ON ADHESIVE

SYSTEM INITIALIZATION

PLACE SMART TRANSMITTER ON ADHESIVE

The center of the patch is sticky, and this is where you should place your smart transmitter, as shown.

Press the smart transmitter firmly onto the adhesive.

Then, remove the larger piece
of the remaining clear backing
on the adhesive patch.

Now you are ready for step 3 – positioning the Eversense
E3 Smart Transmitter over
the Eversense E3 sensor.

If you have an over wrap on your arm, you will need to remove it so that
you can see the Tegaderm bandage.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

It’s helpful to understand where your sensor is located. Your health care provider inserted the sensor above the incision, as illustrated here.

This means that the sensor is likely above the center of your Tegaderm bandage.

Hide bandage

Show bandage

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

There may also be visible marks where your health care provider marked the corners of the smart transmitter before placing your sensor. Aligning the smart transmitter in this location helps to place it appropriately over the sensor.

Go to a mirror, if needed, in order to clearly see your Tegaderm bandage.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Then, open the Placement Guide in your app by going to Main Menu 

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

 – Placement Guide.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Then, open the Placement Guide in your app by going to Main Menu 

You’ll see a black X at first.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Hold the smart transmitter with adhesive as shown – with the sides of the adhesive patch pulled back. If visible, use the smart transmitter corner marks on your skin to position the smart transmitter – toward the top half of the Tegaderm bandage.

Note that the smart transmitter needs to be touching your arm.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Gently lift and slightly move the smart transmitter plus adhesive to find the location with the strongest signal, somewhere between 2-3 bars or good to excellent.

Rotating the smart transmitter slightly may help.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

4 screens

When moving the transmitter, allow a few seconds for the signal to update before moving the transmitter again.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Once you have obtained a signal of two to three bars leave the smart transmitter on your arm there.

Remove the smaller remaining piece of clear backing and smooth out the adhesive patch.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Close the Placement Guide by tapping the menu icon.

The adhesive patch will need to be replaced daily. With practice, you’ll quickly become an expert at positioning your smart transmitter.

SYSTEM INITIALIZATION

POSITION SMART TRANSMITTER OVER SENSOR

Now that you’ve successfully positioned your Eversense E3 Smart Transmitter,
you’ll see a Calibrate Now notification appear in your mobile app within a few minutes.

This means it’s time to do your first of four 4 fingerstick calibrations.

SYSTEM INITIALIZATION

4 INITIALIZATION CALIBRATIONS

The four calibrations can be completed in
as little as 6 hours,

as you can calibrate
as often as every 2 hours.

And, calibrations must be entered
no more than 12 hours apart.

But, you won’t have to remember the time for each calibration because your Eversense E3 CGM System will remind you each time with
a calibrate now notification.

SYSTEM INITIALIZATION

4 INITIALIZATION CALIBRATIONS

To enter a calibration, do a fingerstick blood glucose check ...

... and tap on the blue Calibrate button.

SYSTEM INITIALIZATION

ENTER A CALIBRATION

SYSTEM INITIALIZATION

ENTER A CALIBRATION

Tap on Glucose...

SYSTEM INITIALIZATION

ENTER A CALIBRATION

Tap on Glucose...

... and scroll to enter the correct blood glucose value

then tap Done.

SYSTEM INITIALIZATION

ENTER A CALIBRATION

Tap on Glucose...

Confirm that the correct glucose values has been entered, then tap Submit.

... and scroll to enter the correct blood glucose value

then tap Done.

Tap on Glucose...

You'll receive a Calibration in Progress notification which you can clear by tapping OK.

SYSTEM INITIALIZATION

ENTER A CALIBRATION

Confirm that the correct glucose values has been entered, then tap Submit.

... and scroll to enter the correct blood glucose value

then tap Done.

Here’s an example of how that might work:

so their warm-up phase ends
at 9:45 AM on Tuesday.

Let’s say a user linked their sensor and smart transmitter at 9:45 am on Monday,

SYSTEM INITIALIZATION

SYSTEM INITIALIZATION CALIBRATIONS

Warm up ends:  9:45AM

They then use the Placement Guide to place the smart transmitter on their arm over the sensor, and at about 10:00 AM they get their first Calibrate Now notification. They perform a fingerstick
BG check and enter that value into the mobile app.

SYSTEM INITIALIZATION

SYSTEM INITIALIZATION CALIBRATIONS

Warm up ends:  9:45AM

1st calibration:  10:00 AM

Here’s an example of how that might work:

2 hours later, the 2nd Calibrate Now notification appears, and once that 2nd blood glucose value is
entered
, sensor glucose
data begins to appear
on the My Glucose
home screen.

SYSTEM INITIALIZATION

SYSTEM INITIALIZATION CALIBRATIONS

Warm up ends:  9:45AM

1st calibration:  10:00 AM

2nd calibration:  12:00 PM

Here’s an example of how that might work:

Calibration prompts #3 and #4 will follow in the same fashion.

But remember, you don’t have to calibrate right away – you have up
to 12 hours to perform the next required calibration. But it is ideal to complete all 4 before going to bed, so that you will have the benefit of continuous data that first night.

Warm up ends:  9:45AM

1st calibration:  10:00 AM

2nd calibration:  12:00 PM

3rd calibration:  2:00 PM

4th calibration:  4:00 PM

SYSTEM INITIALIZATION

SYSTEM INITIALIZATION CALIBRATIONS

Here’s an example of how that might work:

Once you have completed the 4 initialization calibrations, and are receiving continuous glucose data, you will enter the 2 Daily Calibration phase.

For the next 21-days you will need to calibrate 2 times per day. After that, you’ll be required to calibrate at least once, but no more than two times, per day.

SYSTEM INITIALIZATION